Mythic Therapeutics Launches with New Approach to Improving Antibody Drug Conjugate Performance, Backed by $103 Million in Series B Financing

Mythic’s FateControl™ technology holds the potential to dramatically improve the therapeutic index of ADCs, independent of the linker and payload

WALTHAM, Mass.–(BUSINESS WIRE)–Mythic Therapeutics today announced its launch to develop smarter and safer antibody-drug conjugates (ADCs) with an oversubscribed Series B financing round of $103 million. Viking Global Investors led the round, along with new investors including Venrock Healthcare Capital Partners, Foresite Capital, Perceptive Advisors, and Highside Capital. Existing Mythic investors participating in the round include Venrock, First Round Capital, OMX Ventures, Lifeforce Capital, and Refactor Capital. The proceeds from Mythic’s Series B will finance the lead program through first-in-human clinical studies in lung cancer and fund pipeline development.

“We are thrilled to partner with this distinguished group of investors,” said Alex Nichols, PhD, co-founder, President, and CEO of Mythic Therapeutics. “This financing validates the FateControl approach and supports our efforts to achieve expanded use of Mythic’s ADCs within and across indications, translating to improved outcomes for patients with unmet medical needs.”

Although the development history of ADCs spans more than four decades, the clinical benefit of ADCs has so far remained limited to a subset of diseases and targets with optimal biological characteristics, such as high levels of target expression. Mythic has developed a breakthrough approach to expand the role of ADCs in precision medicine by dramatically improving ADC therapeutic index against a broad set of molecular targets and patient profiles.

“To date, approaches to improve the performance of ADCs have focused primarily on innovation in one of three dimensions: linker and payload chemistries, conjugation technology, and new target biology,” said Brian Fiske, PhD, co-founder and Chief Scientific Officer of Mythic Therapeutics. “Mythic seeks to improve the clinical performance of ADCs by introducing a new dimension of ADC technology focused on manipulating the fate of ADCs within the cell.”

ADCs are designed to specifically deliver a therapeutic payload to a target tissue or disease site. However, studies have demonstrated that the vast majority of payload is ultimately released non-specifically throughout the body, causing systemic toxicity and reducing efficacy. Mythic’s FateControl™ technology increases the amount of ADC that is internalized by the target tissue while reducing payload release in non-targeted tissues, thereby improving therapeutic index independent of the linker and payload. Mythic’s lead program in lung cancer has the potential to drive a multi-fold expansion of the number of lung cancer patients eligible for treatment using ADCs; the company plans on developing a pipeline of products incorporating its platform technology.

“Venrock was attracted by Mythic’s innovative strategy to overcome one of the most historically challenging obstacles to realizing the full potential of ADCs for patients,” said Bryan Roberts of Venrock, a member of Mythic’s Board of Directors. “The progress this team has made in a short time reinforces our deep conviction in Mythic’s ability to develop a pipeline of safer and more effective ADCs, beginning with their lead program. We are delighted to be part of the Mythic story.”

Leadership

• Alex Nichols, PhD, Co-Founder, President, CEO, and Director
• Brian Fiske, PhD, Co-Founder, Chief Scientific Officer, and Director
• Sandra Poole, MASc, PEng, Chief Operating Officer

In addition to Alex and Brian, the Mythic Therapeutics Board of Directors is comprised of:

• Bryan Roberts, PhD, Partner, Venrock
• Josh Kopelman, Partner, First Round Capital
• Peter Hecht, PhD, Co-Founder and CEO, Cyclerion; Co-Founder and former CEO, Ironwood Pharmaceuticals

Scientific Advisory Board

• Douglas E. Williams, PhD, President and CEO, Codiak Biosciences
• John Lambert, PhD, former EVP and CSO, ImmunoGen
• Michael Vasconcelles, MD, Chief Medical Officer, Flatiron Health
• Richard Gregory, PhD, former CSO, ImmunoGen and former head of R&D, Sanofi
• Scott J. Dylla, PhD, Co-Founder and Former CSO, Stemcentrx

About Mythic Therapeutics

Mythic Therapeutics is a product-platform company developing a pipeline of antibody-drug conjugates (ADCs) designed to exhibit unparalleled therapeutic index and efficacy. The Company’s FateControl technology specifically enhances ADC uptake in targeted tissues by manipulating the fate of the ADC within the cell, thereby expanding the disease and patient profiles that can be treated with Mythic’s ADCs. For more information, visit: www.mythictx.com

Contacts

Investors:

investors@mythictx.com

Media:

Mariesa Kemble

kemblem@mac.com