Information on the Total Number of Voting Rights (Denominator) following Conversion of Negma Convertible Bonds and Partial Reimbursement of Kreos/Pontifax Convertible Bonds

Negma Group has converted 180 convertible bonds resulting in a EUR 450,000 capital increase and Kreos/Pontifax convertible bonds have been reimbursed in an amount of EUR 3 million

Leuven, BELGIUM, Boston, MA, US – June 30 , 2022 – 8.00 PM CET – In accordance with article 15 of the Belgian Act of May 2, 2007 on the disclosure of major participations in issuers of which shares are admitted to trading on a regulated market and regarding miscellaneous provisions, Oxurion NV (Euronext Brussels: OXUR) (the “Company” or “Oxurion”), announces the below information concerning the conversion of the Negma bonds, following the issuance of 1,216,216 new ordinary shares on June 7 (as listed on June 9), 2022, for a total amount of EUR 450,000, as the result of the conversion of 180 convertible bonds pursuant to the Capital Commitment entered into with Negma Group.

Following completion of the capital increase through the conversion of the Negma convertible bonds the total number of shares issued by Oxurion amounts to 49,821,189 outstanding ordinary shares carrying voting rights (compared to 48,604,973 outstanding ordinary shares previously). This number will be used as the denominator for the calculation of the percentages of shareholdings.

In addition, Oxurion has reimbursed EUR 3 million (30%) of the Kreos/Pontifax Convertible Bonds issued in December 2021. Within that framework, the cash covenant has been reduced from EUR 4 million to EUR 3 million and the interest-only period has been extended until the end of the third quarter of 2022. The reimbursement reduces the total number of shares to be issued upon a potential conversion of the Kreos/Pontifax Convertible Bonds by 1,034,482 shares without impacting the cash runway included in the Company’s Prospectus issued in March 2022.

Therefore, Oxurion publishes the following updated information:

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About Oxurion

Oxurion (Euronext Brussels: OXUR) is a biopharmaceutical company developing next generation standard of care ophthalmic therapies, which are designed to improve and better preserve vision in patients with retinal disorders including diabetic macular edema (DME), the leading cause of vision loss in working-age people, as well as other conditions. Oxurion intends to play an important role in the treatment of retinal disorders, including the successful development of THR-149, its novel therapeutic for the treatment of DME. THR-149 is a potent plasma kallikrein inhibitor being developed as a potential new standard of care for the up to 50% of DME patients showing suboptimal response to anti-VEGF therapy. Oxurion is headquartered in Leuven, Belgium, with corporate operations in Boston, MA. More information is available at www.oxurion.com.

Important information about forward-looking statements

Certain statements in this press release may be considered “forward-looking”. Such forward-looking statements are based on current expectations, and, accordingly, entail and are influenced by various risks and uncertainties. The Company therefore cannot provide any assurance that such forward-looking statements will materialize and does not assume any obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or any other reason. Additional information concerning risks and uncertainties affecting the business and other factors that could cause actual results to differ materially from any forward-looking statement is contained in the Company’s Annual Report. This press release does not constitute an offer or invitation for the sale or purchase of securities or assets of Oxurion in any jurisdiction. No securities of Oxurion may be offered or sold within the United States without registration under the U.S. Securities Act of 1933, as amended, or in compliance with an exemption therefrom, and in accordance with any applicable U.S. state securities laws.

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• OXUR PR_Voting rights (ENG)_20220630